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The HPFS began in 1986 when 51?529 US male health professionals, aged 40 to 75 years, completed a baseline questionnaire on medical history and lifestyle practices. Health professionals are highly motivated and committed to participating in this long-term project and appreciate the accuracy of reports, given their knowledge and medical background. Biennially, participants received a questionnaire, and a response rate exceeding 90% has been achieved in the follow-up. The study was approved by the Human Research Committee at Brigham and Women’s Hospital, Boston, Massachusetts. Participants’ completion and return of the questionnaire was considered informed consent.36. Savitz SA, Caplan LR "Transient global amnesia after sildenafil (Viagra) use." Neurology 59 (2002): 778
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